The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effectswhich can avoid chemo-resistance pathways. The potential photodynamic activity of twofluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells..
Photodynamic activity of thiophene-derived lysosome-specific dyes
BALDASSARRE, FRANCESCAPrimo
;TEPORE, AntonioPenultimo
;CICCARELLA, Giuseppe
Ultimo
2016-01-01
Abstract
The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effectswhich can avoid chemo-resistance pathways. The potential photodynamic activity of twofluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells..File in questo prodotto:
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