A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.
Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C
Messa, Francesco;Paparella, Andrea Nicola;Perrone, Serena
;Salomone, Antonio
2022-01-01
Abstract
A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.File in questo prodotto:
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