Hyaluronic acid (HA), also termed hyaluronan, is a key extracellular matrix glycosaminoglycan that not only provides tissue hydration, but also shows intrinsic bioactivity towards cellular proliferation, differentiation and inflammatory response. These properties make HA attractive both as a potential target for the treatment of several diseases and as an effective biomaterial to control cell behavior. This concise review aims at emphasizing the increasing role of HA as a promising biomaterial for advanced medical applications that include, among others, the development of targeted therapies for cancer treatment and the development of scaffolds for regenerative medicine. Although the bioactive mechanisms of HA are not fully understood, its molecular weight and purity are well known to affect the cellular and immunological responses to HA-based products. Furthermore, in spite of the complex translation of novel HA-based medical devices from the lab bench to the clinic, a rapid growth of the HA market is foreseen in the next future, also due to the growing aging of the population and the increasing demand for anti-aging products. In this perspective, the industrial HA production is briefly addressed, with reference to the technological issues that are currently undergoing extensive research to improve the HA yield and quality, in an attempt to meet the quickly rising HA demand.

Hyaluronic acid for advanced therapies: Promises and challenges

Gallo N.
;
Salvatore L.;Capobianco L.;Sannino A.;Madaghiele M.
2019

Abstract

Hyaluronic acid (HA), also termed hyaluronan, is a key extracellular matrix glycosaminoglycan that not only provides tissue hydration, but also shows intrinsic bioactivity towards cellular proliferation, differentiation and inflammatory response. These properties make HA attractive both as a potential target for the treatment of several diseases and as an effective biomaterial to control cell behavior. This concise review aims at emphasizing the increasing role of HA as a promising biomaterial for advanced medical applications that include, among others, the development of targeted therapies for cancer treatment and the development of scaffolds for regenerative medicine. Although the bioactive mechanisms of HA are not fully understood, its molecular weight and purity are well known to affect the cellular and immunological responses to HA-based products. Furthermore, in spite of the complex translation of novel HA-based medical devices from the lab bench to the clinic, a rapid growth of the HA market is foreseen in the next future, also due to the growing aging of the population and the increasing demand for anti-aging products. In this perspective, the industrial HA production is briefly addressed, with reference to the technological issues that are currently undergoing extensive research to improve the HA yield and quality, in an attempt to meet the quickly rising HA demand.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11587/430897
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