Integration of PLGA Microparticles in Collagen-Based Matrices: Tunable Scaffold Properties and Interaction Between Microparticles and Human Epithelial-Like Cells

Gallo, L. C.; Madaghiele, M.; Salvatore, L.; Barca, A.; Scialla, S.; Bettini, S.; Valli, L.; Verri, T.; Bucalá, V.; Sannino, A.

doi:10.1080/00914037.2018.1552857

The feasibility to obtain highly porous collagen-based scaffolds (SCs) integrated with uniformly dispersed poly (lactide-co-glycolide)(PLGA) microparticles (MPs) was evaluated. PLGA-MPs were prepared by double emulsion technique and SCs with different amounts of MPs (SC/PLGA-MPs) were produced. Results showed that SC/PLGA-MPs could be successfully manufactured, the PLGA-MPs being physically retained in the SCs, without affecting the porous structure. PLGA-MPs also increased the SC hydrophilicity, acted as a mechanical reinforcement and retarded the degradation rate. In addition, the interactions between MPs and Caco-2 cells did not interfere with the correct morphological, adhesion and proliferation pathways.

Titolo:	Integration of PLGA Microparticles in Collagen-Based Matrices: Tunable Scaffold Properties and Interaction Between Microparticles and Human Epithelial-Like Cells
Autori:	Gallo, L. C. MADAGHIELE, Marta SALVATORE, LUCA BARCA, AMILCARE Scialla, S. BETTINI, SIMONA VALLI, Ludovico VERRI, Tiziano Bucalá, V. SANNINO, Alessandro mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Rivista:	INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS
Abstract:	The feasibility to obtain highly porous collagen-based scaffolds (SCs) integrated with uniformly dispersed poly (lactide-co-glycolide)(PLGA) microparticles (MPs) was evaluated. PLGA-MPs were prepared by double emulsion technique and SCs with different amounts of MPs (SC/PLGA-MPs) were produced. Results showed that SC/PLGA-MPs could be successfully manufactured, the PLGA-MPs being physically retained in the SCs, without affecting the porous structure. PLGA-MPs also increased the SC hydrophilicity, acted as a mechanical reinforcement and retarded the degradation rate. In addition, the interactions between MPs and Caco-2 cells did not interfere with the correct morphological, adhesion and proliferation pathways.
Handle:	http://hdl.handle.net/11587/429249
Appare nelle tipologie:	Articolo pubblicato su Rivista

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