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EnglishA novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic α-chloro oximes with aliphatic amines at 110 °C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds.
| Titolo: | Green synthesis of 2-pyrazinones in deep eutectic solvents: From α-chloro oximes to peptidomimetic scaffolds |
| Autori: | |
| Data di pubblicazione: | 2017 |
| Rivista: | |
| Abstract: | A novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic α-chloro oximes with aliphatic amines at 110 °C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds. |
| Handle: | http://hdl.handle.net/11587/428877 |
| Appare nelle tipologie: | Articolo pubblicato su Rivista |
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