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EnglishWe introduce a class of weighted graphs whose properties are meant to mimic the topological features of idiotypic networks, namely, the interaction networks involving the B core of the immune system. Each node is endowed with a bit string representing the idiotypic specificity of the corresponding B cell, and the proper distance between any couple of bit strings provides the coupling strength between the two nodes. We show that a biased distribution of the entries in bit strings can yield fringes in the (weighted) degree distribution, small-world features, and scaling laws, in agreement with experimental findings. We also investigate the role of aging, thought of as a progressive increase in the degree of bias in bit strings, and we show that it can possibly induce mild percolation phenomena, which are investigated too.
| Titolo: | Organization and evolution of synthetic idiotypic networks |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| Abstract: | We introduce a class of weighted graphs whose properties are meant to mimic the topological features of idiotypic networks, namely, the interaction networks involving the B core of the immune system. Each node is endowed with a bit string representing the idiotypic specificity of the corresponding B cell, and the proper distance between any couple of bit strings provides the coupling strength between the two nodes. We show that a biased distribution of the entries in bit strings can yield fringes in the (weighted) degree distribution, small-world features, and scaling laws, in agreement with experimental findings. We also investigate the role of aging, thought of as a progressive increase in the degree of bias in bit strings, and we show that it can possibly induce mild percolation phenomena, which are investigated too. |
| Handle: | http://hdl.handle.net/11587/414624 |
| Appare nelle tipologie: | Articolo pubblicato su Rivista |
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