Design and synthesis of cellulose derivatives with antioxidant activity

Trombino, Sonia; Cassano, Roberta; Bloise, Ermelinda; Muzzalupo, Rita; Leta, Sonia; Puoci, Francesco; Picci, Nevio

doi:10.1002/mabi.200700110

In this study we report the synthesis and characterisation of cellulose ferulate, lipoate and alpha-tocopherulate, and their ability to inhibit lipid peroxidation in rat-liver microsomal membranes, induced in vitro by two different sources of free radicals: tert-butyl hydroperoxide and 2,2'-azobis-(2-amidinopropane). We also compared the antioxidant efficiency of the ferulate derivatives obtained through two different synthetic runs, and of a tocopherulate derivative prepared from 6-carboxycellulose. This study showed that the designed systems, preserving the antioxidant activity of the free substrates, are more effective in protecting from tert-butyl hydroperoxide than from 2,2'-azobis-(2-amidinopropane). Moreover, the cellulose ferulate with the higher degree of substitution acted as the best antioxidant.

Titolo:	Design and synthesis of cellulose derivatives with antioxidant activity
Autori:	Trombino, Sonia Cassano, Roberta BLOISE, ERMELINDA Muzzalupo, Rita Leta, Sonia PUOCI, Francesco Picci, Nevio mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2008
Rivista:	MACROMOLECULAR BIOSCIENCE
Abstract:	In this study we report the synthesis and characterisation of cellulose ferulate, lipoate and alpha-tocopherulate, and their ability to inhibit lipid peroxidation in rat-liver microsomal membranes, induced in vitro by two different sources of free radicals: tert-butyl hydroperoxide and 2,2'-azobis-(2-amidinopropane). We also compared the antioxidant efficiency of the ferulate derivatives obtained through two different synthetic runs, and of a tocopherulate derivative prepared from 6-carboxycellulose. This study showed that the designed systems, preserving the antioxidant activity of the free substrates, are more effective in protecting from tert-butyl hydroperoxide than from 2,2'-azobis-(2-amidinopropane). Moreover, the cellulose ferulate with the higher degree of substitution acted as the best antioxidant.
Handle:	http://hdl.handle.net/11587/409466
Appare nelle tipologie:	Articolo pubblicato su Rivista

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