A range of pyrazol-5-one and pyrazol-3-one derivatives has been synthesized in a single step via a palladium- catalyzed carbonylation of aromatic or aliphatic a-chloroketones, in the presence of aromatic or aliphatic hydrazines. A reaction mechanism, explaining the observed regioselectivity, has been also discussed.
Palladium-catalyzed carbonylative coupling of α-chloroketones with hydrazines: a simple route to pyrazolone derivatives
CAPUA, MARTINA;GRANITO, Catia;PERRONE, SERENA;Salomone, Antonio;TROISI, Luigino
2016-01-01
Abstract
A range of pyrazol-5-one and pyrazol-3-one derivatives has been synthesized in a single step via a palladium- catalyzed carbonylation of aromatic or aliphatic a-chloroketones, in the presence of aromatic or aliphatic hydrazines. A reaction mechanism, explaining the observed regioselectivity, has been also discussed.File in questo prodotto:
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