A simple and direct method to obtain 3-acyl-4-hydroxy-2-pyranone derivatives by the palladium-catalyzed carbonylation of a-chloroketones has been described. The methodology can be applied to a variety of aromatic and aliphatic ketones to afford valuable products from both a synthetic and a biological point of view. A mechanistic hypothesis involving an acylketene intermediate has also been proposed.

A direct synthesis of 3-acyl-4-hydroxy-2-pyranone derivatives via palladium-catalyzed carbonylation of α-chloroketones. A cascade reaction involving acylketenes

PERRONE, SERENA;CAROLI, ANTONIO;GRANITO, Catia;Salomone, Antonio;TROISI, Luigino
2015-01-01

Abstract

A simple and direct method to obtain 3-acyl-4-hydroxy-2-pyranone derivatives by the palladium-catalyzed carbonylation of a-chloroketones has been described. The methodology can be applied to a variety of aromatic and aliphatic ketones to afford valuable products from both a synthetic and a biological point of view. A mechanistic hypothesis involving an acylketene intermediate has also been proposed.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11587/406835
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 12
social impact