The paper reports the first chemical synthesis of a-D-glucopyranosyl-(1->2)-b-D-galactopyranosyl-5-O-hydroxylysine, a biological marker of bone resorption and of its unnatural (5S)-epimer, starting from commercial sugars and amino acids. Moreover, the synthetic protocol set-up has resulted in a new procedure for the synthesis of the b-D-galactopyranosyl-5-O-hydroxylysine and its unnatural (5S)-epimer.
Hydroxylysine containing glycoconjugates: an efficient synthesis of natural galactosylhydroxylysine (Gal-Hyl) and glucosylgalactosylhydroxylysine (Glu-Gal-Hyl) and of their (5S)-epimers
RAGUSA, ANDREA;
2004-01-01
Abstract
The paper reports the first chemical synthesis of a-D-glucopyranosyl-(1->2)-b-D-galactopyranosyl-5-O-hydroxylysine, a biological marker of bone resorption and of its unnatural (5S)-epimer, starting from commercial sugars and amino acids. Moreover, the synthetic protocol set-up has resulted in a new procedure for the synthesis of the b-D-galactopyranosyl-5-O-hydroxylysine and its unnatural (5S)-epimer.File in questo prodotto:
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