E-cadherin is the core protein of the epithelial adherens junction. Through its cytoplasmic domain, E-cadherin interacts with additional proteins among which catenins that bridge it to the actin cytoskeletal. Loss of E-cadherin expression is considered a crucial step in the epithelial–mesenchymal transition process (EMT) and it is implicated with the capacity of cancer cells to invade and metastasize.
Proteomics analysis of E-cadherin knockdown epithelial breast cancer cells
LATORRE, DOMINGA;VERGARA, DANIELE;GIUDETTI, Anna Maria;CAPOBIANCO, Loredana;Lunetti P.;RIZZELLO, Antonia;MAFFIA, Michele
2014-01-01
Abstract
E-cadherin is the core protein of the epithelial adherens junction. Through its cytoplasmic domain, E-cadherin interacts with additional proteins among which catenins that bridge it to the actin cytoskeletal. Loss of E-cadherin expression is considered a crucial step in the epithelial–mesenchymal transition process (EMT) and it is implicated with the capacity of cancer cells to invade and metastasize.File in questo prodotto:
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