In this paper we explore relevant electrical properties of two olfactory receptors (ORs), the rat OR I7 and the human, OR 17-40, which are of interest for the realization of smell nanobiosensors. We compare existing experiments, carried out by electrochemical impedance spectroscopy, with theoretical expectations obtained from an impedance network protein analogue, recently developed. The changes in the electrical response due to the sensing action of the proteins are correlated with the conformational change undergone by the single protein. The satisfactory agreement between theory and experiments points to a promising development of a new class of nanobiosensors based on the electrical properties of sensing proteins.
Olfactory receptors for a smell sensor: A comparative study of the electrical responses of rat I7 and human 17-40
ALFINITO, ELEONORA;MILLITHALER, JEAN FRANCOIS ANTOINE PHILIPPE;REGGIANI, Lino
2011-01-01
Abstract
In this paper we explore relevant electrical properties of two olfactory receptors (ORs), the rat OR I7 and the human, OR 17-40, which are of interest for the realization of smell nanobiosensors. We compare existing experiments, carried out by electrochemical impedance spectroscopy, with theoretical expectations obtained from an impedance network protein analogue, recently developed. The changes in the electrical response due to the sensing action of the proteins are correlated with the conformational change undergone by the single protein. The satisfactory agreement between theory and experiments points to a promising development of a new class of nanobiosensors based on the electrical properties of sensing proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
