Receptors for the Fc fragment of immunoglobulin G (FcgammaRs) are important molecules not only to mediate and control the effectors' functions of IgG antibodies, but they also control the autoimmunity-tolerance balance in the periphery. In humans, three different types of FcgammaRs, belonging to the Ig gene superfamily, have been identified; FcgammaRI (cluster of differentiation (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16). A wide range of inflammatory and autoimmune diseases, such as vasculitis, glomerulonephritis, and autoimmune hemolytic anemia, seems to be mediated, in part, by FcgammaRs. Recent findings supposed that, under certain conditions, FcgammaRs are involved in the penetration of antibodies into cells and FcgammaRs constitute one of the main effector mechanisms through which autoantibodies exert their action. In this review, we concentrate on the role of human FcgammaRs in autoantibodies penetration and summarize the current knowledge on the structure, ligand binding capacity and their role in autoimmunity and pathogenic effect of autoantibodies.
Advances in the understanding of the Fc gamma 3 receptors-mediated autoantibodies uptake
LOFRUMENTO, Dario DomenicoMembro del Collaboration Group
;
2011-01-01
Abstract
Receptors for the Fc fragment of immunoglobulin G (FcgammaRs) are important molecules not only to mediate and control the effectors' functions of IgG antibodies, but they also control the autoimmunity-tolerance balance in the periphery. In humans, three different types of FcgammaRs, belonging to the Ig gene superfamily, have been identified; FcgammaRI (cluster of differentiation (CD64), FcgammaRII (CD32) and FcgammaRIII (CD16). A wide range of inflammatory and autoimmune diseases, such as vasculitis, glomerulonephritis, and autoimmune hemolytic anemia, seems to be mediated, in part, by FcgammaRs. Recent findings supposed that, under certain conditions, FcgammaRs are involved in the penetration of antibodies into cells and FcgammaRs constitute one of the main effector mechanisms through which autoantibodies exert their action. In this review, we concentrate on the role of human FcgammaRs in autoantibodies penetration and summarize the current knowledge on the structure, ligand binding capacity and their role in autoimmunity and pathogenic effect of autoantibodies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
