This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and 15 MRI the relationship between PBMCs protein expression profile and whole brain atrophy in 16 unselected 16 RR-MS IFN-treated patients compared with 6 RRIFN-untreated and 12 matched healthy control subjects. 17 Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. 18 Twenty six proteins showed significant differential expression among RR IFN-treated patients and control 19 samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR 20 IFN-treated MS patients. 21 Future clinical applications remain to be validated by other techniques and confirmed by a larger study.

PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: a pilot study on relation to clinical findings and brain atrophy

VERGARA, DANIELE;ACIERNO, Raffaele;GRECO, MARILENA;MAFFIA, Michele
2009-01-01

Abstract

This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and 15 MRI the relationship between PBMCs protein expression profile and whole brain atrophy in 16 unselected 16 RR-MS IFN-treated patients compared with 6 RRIFN-untreated and 12 matched healthy control subjects. 17 Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. 18 Twenty six proteins showed significant differential expression among RR IFN-treated patients and control 19 samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR 20 IFN-treated MS patients. 21 Future clinical applications remain to be validated by other techniques and confirmed by a larger study.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11587/328483
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