Cell movement plays an important role in many processes, such as immune response and wound healing[1]. Physical environment surrounding cells is a key factor in response of cells to surfaces. Recent studies have shown that cell movement is sensitive to the rigidity of the substrate, a phenomenon defined as “mechanotaxis or durotaxis”[2]. The purpose of this study is to investigate cell migration by fabricating uniform substrates imposing different mechanical stiffness with patterns of various shapes.

Cells response sensing durotaxis by varying mechanical rigidity

GIGLI, Giuseppe;CINGOLANI, Roberto
2008-01-01

Abstract

Cell movement plays an important role in many processes, such as immune response and wound healing[1]. Physical environment surrounding cells is a key factor in response of cells to surfaces. Recent studies have shown that cell movement is sensitive to the rigidity of the substrate, a phenomenon defined as “mechanotaxis or durotaxis”[2]. The purpose of this study is to investigate cell migration by fabricating uniform substrates imposing different mechanical stiffness with patterns of various shapes.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11587/327841
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