α-chloroheteroarylalkyllithiums generated by deprotonation of 2-(1-chloroalkyl)-heterocycles with n-BuLi in THF at –78 °C, were found to react as Darzens-type reagents with racemic and optically pure 2- and 3-methylcyclohexanones. Heteroaryloxiranes containing new stereocentres were isolated in a diastereo- and enantioselective manner.
Diastereo- and enantioselective syntheses of heteroaryloxiranes.
TROISI, Luigino;DE VITIS, LUISELLA;GRANITO, Catia;RONZINI, Ludovico
2004-01-01
Abstract
α-chloroheteroarylalkyllithiums generated by deprotonation of 2-(1-chloroalkyl)-heterocycles with n-BuLi in THF at –78 °C, were found to react as Darzens-type reagents with racemic and optically pure 2- and 3-methylcyclohexanones. Heteroaryloxiranes containing new stereocentres were isolated in a diastereo- and enantioselective manner.File in questo prodotto:
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