Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study.

Tenconi, Mt; Devoti, Gabriele; Comelli, M; Pinon, M; Capocchiano, A; Calcaterra, V; AND THE PAVIA T1DM REGISTRY GROUP, Pretti G.

doi:10.1007/s00592-007-0235-9

Aims - Evaluation of the association among infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. Methods - A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Results - Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly associated to type 1 diabetes; an inverse association was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Conclusions - Most associations of the studied variables confirm already known findings. The significant inverse association of type 1 diabetes with scarlet fever history is a peculiar finding, whose meaning is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.

Titolo:	Major childhood infectious diseases and other determinants associated with type 1 diabetes: a case-control study.
Autori:	TENCONI MT DEVOTI, Gabriele COMELLI M PINON M CAPOCCHIANO A CALCATERRA V PRETTI G. AND THE PAVIA T1DM REGISTRY GROUP mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2007
Rivista:	ACTA DIABETOLOGICA
Abstract:	Aims - Evaluation of the association among infectious diseases and other events pertaining to childhood medical history and type 1 diabetes. Methods - A case-control study was carried out, taking as cases 159 type 1 diabetic patients (0-29 years) recorded from 1988 to 2000 within the population registry of the Pavia province (North Italy). As controls 318 non diabetic subjects were matched by age and sex. A questionnaire was administered by standardised interviewers. Data were analysed by conditional logistic regression. Results - Viral childhood diseases (OR 4.29; 95%CI 1.57-11.74) and bottle feeding (OR 1.83; 95%CI 1.08-3.09) were directly associated to type 1 diabetes; an inverse association was found for vitamin D administration during lactation (0-14 years) (OR 0.31; 95%CI 0.11-0.86) and for history of scarlet fever in both sexes and age groups (OR 0.19; 95%CI 0.08-0.46). Conclusions - Most associations of the studied variables confirm already known findings. The significant inverse association of type 1 diabetes with scarlet fever history is a peculiar finding, whose meaning is still obscure, although it has been recently described that streptococcal A infections are regulated by HLA class II alleles.
Handle:	http://hdl.handle.net/11587/109037
Appare nelle tipologie:	Articolo pubblicato su Rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11587/109037

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CINECA IRIS Institutional Research Information System

File in questo prodotto: