[2+2] Carbonylative cycloaddition of chiral imines to various allyl halides, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2 and PPh3 as ligand, are carried out. Separable diastereomeric mixtures of chiral alkenyl-b-lactams are isolated with good yields and high trans diastereoselections. Absolute configurations are assigned by X-ray measurements and 1H NMR spectroscopy.
Titolo: | [2+2 ] Carbonylative cycloaddition catalyzed by palladium: stereoselective synthesis of b-lactams. |
Autori: | |
Data di pubblicazione: | 2004 |
Rivista: | |
Abstract: | [2+2] Carbonylative cycloaddition of chiral imines to various allyl halides, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2 and PPh3 as ligand, are carried out. Separable diastereomeric mixtures of chiral alkenyl-b-lactams are isolated with good yields and high trans diastereoselections. Absolute configurations are assigned by X-ray measurements and 1H NMR spectroscopy. |
Handle: | http://hdl.handle.net/11587/108769 |
Appare nelle tipologie: | Articolo pubblicato su Rivista |
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