The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg(-1)). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml(-1) kg(-1) 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg.h kg(-1) and the elimination half-life of 1.83 h.

Pharmacokinetics of cephalexin in sea bream, Sparus aurata (L.), after a single intraperitoneal injection

VERRI, Tiziano;MAFFIA, Michele
2004

Abstract

The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg(-1)). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml(-1) kg(-1) 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg.h kg(-1) and the elimination half-life of 1.83 h.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11587/108619
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