Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates

Balaz, M.; Holmes, A. E.; Benedetti, Michele; Rodriguez, P. C.; Berova, N.; Nakanishi, K.; Proni, G.

doi:10.1021/ja043373z

The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.

Titolo:	Synthesis and circular dichroism of tetraarylporphyrin-oligonucleotide conjugates
Autori:	M. BALAZ A. E. HOLMES BENEDETTI, MICHELE P. C. RODRIGUEZ N. BEROVA K. NAKANISHI G. PRONI mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2005
Rivista:	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Abstract:	The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3- end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 Å), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.
Handle:	http://hdl.handle.net/11587/106001
Appare nelle tipologie:	Articolo pubblicato su Rivista

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http://hdl.handle.net/11587/106001

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