In this work chemically crosslinked superabsorbent hydrogels have been synthesized from water solutions of hydroxyethylcellulose (HEC), carboxymethylcellulose sodium Salt (CMCNa) and hyaluronic acid (HA), using a non-toxic water-soluble carbodiimide (WSC) as crosslinking agent. Sorption capacity both in water and in water solutions at different ionic strength has been investigated, taking into account the effect of different chemical compositions. Moreover, unaxial compression tests and dynamic-mechanical measurements on water swollen samples have been performed to probe the elastically effective degree of crosslinking of the polymeric network. In vivo tests on humans for the application of this material as a bulking agent in dietary regimes are in process and preliminary results are encouraging.
Crosslinking of cellulose derivatives and hyaluronic acid with water soluble carbodiimide
SANNINO, Alessandro;MADAGHIELE, Marta;MAFFEZZOLI, Alfonso;
2005-01-01
Abstract
In this work chemically crosslinked superabsorbent hydrogels have been synthesized from water solutions of hydroxyethylcellulose (HEC), carboxymethylcellulose sodium Salt (CMCNa) and hyaluronic acid (HA), using a non-toxic water-soluble carbodiimide (WSC) as crosslinking agent. Sorption capacity both in water and in water solutions at different ionic strength has been investigated, taking into account the effect of different chemical compositions. Moreover, unaxial compression tests and dynamic-mechanical measurements on water swollen samples have been performed to probe the elastically effective degree of crosslinking of the polymeric network. In vivo tests on humans for the application of this material as a bulking agent in dietary regimes are in process and preliminary results are encouraging.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
