In the present study, we aimed to investigate the anti-angiogenesis effects of [Pt(O,O’-acac)(γ-acac)(DMS)]. [Pt(O,O′-acac)(γ-acac)(DMS)] significantly inhibited human umbilical vein endothelial cell (HUVEC) proliferation. Then, the ex vivo rat aortic ring capillary-network sprouting has been carried out. It was observed that after one week of treatment under regular growth conditions, [Pt(O,O′-acac)(γ-acac)(DMS)] potently inhibited the sprouting as well as capillary-network formation from rat aortic ring in a dose-dependent manner. Compared to control 0,5 and 1 μM doses of [Pt(O,O′-acac)(γ- acac)(DMS)] suppressed capillary-network formation by 68 to 100%, respectively. In addition, in mouse xenograft model of breast cancer, treatment of mice with [Pt(O,O′-acac)(γ-acac)(DMS)], decrease MMP-1 content in tumours. These observations demonstrated that [Pt(O,O′- acac)(γ-acac)(DMS)] could inhibit angiogenesis, which warrants further studies in other in vivo models.

The Angiosuppressive Effects of [Pt(O,O′-acac)(γ-acac)(DMS)]

MUSCELLA, Antonella
Primo
;
VETRUGNO, CARLA
Secondo
;
CALABRISO, NADIA;FANIZZI, Francesco Paolo;DE PASCALI, SANDRA ANGELICA;MARSIGLIANTE, Santo
Ultimo
2014

Abstract

In the present study, we aimed to investigate the anti-angiogenesis effects of [Pt(O,O’-acac)(γ-acac)(DMS)]. [Pt(O,O′-acac)(γ-acac)(DMS)] significantly inhibited human umbilical vein endothelial cell (HUVEC) proliferation. Then, the ex vivo rat aortic ring capillary-network sprouting has been carried out. It was observed that after one week of treatment under regular growth conditions, [Pt(O,O′-acac)(γ-acac)(DMS)] potently inhibited the sprouting as well as capillary-network formation from rat aortic ring in a dose-dependent manner. Compared to control 0,5 and 1 μM doses of [Pt(O,O′-acac)(γ- acac)(DMS)] suppressed capillary-network formation by 68 to 100%, respectively. In addition, in mouse xenograft model of breast cancer, treatment of mice with [Pt(O,O′-acac)(γ-acac)(DMS)], decrease MMP-1 content in tumours. These observations demonstrated that [Pt(O,O′- acac)(γ-acac)(DMS)] could inhibit angiogenesis, which warrants further studies in other in vivo models.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11587/410224
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