Bioorganometallic chemistry is an emerging area of organometallic chemistry. The presence of a metal in a biomimetic molecule may be useful for the possibility to deliver, a particular metal, to a specific target, for therapeutic and/or imaging purposes. In this work, we report the synthesis of new Pt(II) containing organometallic species, having the same structural core of Vitamin E, a remarkable family of biologically active chromane derivatives. Such compounds are characterized by substitution of the carbon atom in 2 position within the chromane pseudo-pyran heterocycle with a square planar Pt(II) centre, which carries also a chelate dinitrogen ligand. Cytotoxicity and Pt uptake measurements, performed on health or cancer cells, show interesting structure-activity relationships for the new metalla-chromanes.
New organometallic Platinum containing biomimetic Vitamin E analogues.
BENEDETTI, MICHELE;MIGONI, DANILO;DE PASCALI, SANDRA ANGELICA;FANIZZI, Francesco Paolo
2009-01-01
Abstract
Bioorganometallic chemistry is an emerging area of organometallic chemistry. The presence of a metal in a biomimetic molecule may be useful for the possibility to deliver, a particular metal, to a specific target, for therapeutic and/or imaging purposes. In this work, we report the synthesis of new Pt(II) containing organometallic species, having the same structural core of Vitamin E, a remarkable family of biologically active chromane derivatives. Such compounds are characterized by substitution of the carbon atom in 2 position within the chromane pseudo-pyran heterocycle with a square planar Pt(II) centre, which carries also a chelate dinitrogen ligand. Cytotoxicity and Pt uptake measurements, performed on health or cancer cells, show interesting structure-activity relationships for the new metalla-chromanes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
