A Services Oriented System for Bioinformatics Applications on the Grid

This paper describes the evolution of the main services of the ProGen- Grid (Proteomics & Genomics Grid) system, a distributed and ubiquitous grid en- vironment (“virtual laboratory”), based on Workflow and supporting the design, execution and monitoring of “in silico” experiments in bioinformatics. ProGenGrid is a Grid-based Problem Solving Environment that allows the com- position of data sources and bioinformatics programs wrapped as Web Services (WS). The use of WS provides ease of use and fosters re-use. The resulting work- flow of WS is then scheduled on the Grid, leveraging Grid-middleware services. In particular, ProGenGrid offers a modular bag of services and currently is focused on the biological simulation of two important bioinformatics problems: prediction of the secondary structure of proteins, and sequence alignment of proteins. Both services are based on an enhanced data access service.