Cost-analysis of measles-mumps-rubella vaccination according to different patterns of immunisation coverage Objectives: To evaluate the cost-benefit ratio of measles-mumps-rubella vaccination in two Italian areas with different immunisation coverages.Design: On the basis of the epidemiologic patterns of the three diseases inPiemonte and Puglia, the direct and indirect costs of the diseases and vaccinationwere estimated. A hypothetical 5-year vaccination program for children between2 and 6 years of age was designed for the two regions. Setting: Piemonte and Puglia regions from 1995 to 1999, with a MMR immunization coverage of 60% and 40%, respectively.Main outcome measures and results: The variation of the cost-benefit ratioof vaccination was related to immunization coverage (and residual morbidity),cost of the disease (especially indirect costs), efficacy of the vaccine. The ratiowas > 1 when coverage was moderate (40%) with high morbidity and low costsof the disease; with a 60% coverage a ratio of 0.70-0.90 was achieved. Conclusions: The analysis showed that the cost-benefit ratio is affected byseveral factors that can vary within the regional situations. While the cost of aprevented case can be low, public health strategies should also consider the costof residual cases, which can be high when immunisation coverage or vaccineefficacy is low.
COST ANALYSIS OF MEASLES-MUMPS-RUBELLA VACCINATION IN DIFFERENT PATTERNS OF IMMMUNISATION COVERAGE.
DE DONNO, Maria Antonella;
2003-01-01
Abstract
Cost-analysis of measles-mumps-rubella vaccination according to different patterns of immunisation coverage Objectives: To evaluate the cost-benefit ratio of measles-mumps-rubella vaccination in two Italian areas with different immunisation coverages.Design: On the basis of the epidemiologic patterns of the three diseases inPiemonte and Puglia, the direct and indirect costs of the diseases and vaccinationwere estimated. A hypothetical 5-year vaccination program for children between2 and 6 years of age was designed for the two regions. Setting: Piemonte and Puglia regions from 1995 to 1999, with a MMR immunization coverage of 60% and 40%, respectively.Main outcome measures and results: The variation of the cost-benefit ratioof vaccination was related to immunization coverage (and residual morbidity),cost of the disease (especially indirect costs), efficacy of the vaccine. The ratiowas > 1 when coverage was moderate (40%) with high morbidity and low costsof the disease; with a 60% coverage a ratio of 0.70-0.90 was achieved. Conclusions: The analysis showed that the cost-benefit ratio is affected byseveral factors that can vary within the regional situations. While the cost of aprevented case can be low, public health strategies should also consider the costof residual cases, which can be high when immunisation coverage or vaccineefficacy is low.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
